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Given the increasing importance of value chain collaboration, business processes need to be more closely aligned across organizational boundaries. Hence, business process modeling and design have to be enhanced and extended to cope with inter-organizational business relationships. Among the challenges that arise are interdependencies between internal and external processes, different process logic and terminology, missing clarification of responsibilities and confidentiality issues. This paper analyzes existing approaches to business process modeling, workflow management and B2B standardization with regard to the specific requirements concerning inter-organizational business process design. It extracts the relevant concepts addressing these requirements and draws up an agenda for further research.